Journal Articles by V. Obsilova
K. Kohoutova,
P. Srb,
V. Obsilova,
V. Veverka and
T. Obsil
Structural plasticity of the FOXO-DBD:p53-TAD interaction
Structural plasticity of the FOXO-DBD:p53-TAD interaction
Nature Communications,
16(1),
2025
K. Kohoutova,
P. Srb,
V. Obsilova,
V. Veverka and
T. Obsil
Structural plasticity of the FOXO-DBD:p53-TAD interaction
Structural plasticity of the FOXO-DBD:p53-TAD interaction
Nature Communications,
16(1),
2025
M. Janosev,
D. Kosek,
A. Tekel,
R. Joshi,
K. Honzejkova,
P. Pohl,
T. Obsil and
V. Obsilova
Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins
Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins
Nature Communications,
16(1),
2025
V. Obsilova and
T. Obsil
Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins
Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins
Physiol Res,
2024
K. Honzejkova,
D. Kosek,
V. Obsilova and
T. Obsil
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1
eLife,
13,
2024
V. Obsilova and
T. Obsil
The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways
The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways
Frontiers in Molecular Biosciences,
11,
2024
V. Obsilova and
T. Obsil
Structural insights into the functional roles of 14-3-3 proteins
Structural insights into the functional roles of 14-3-3 proteins
Frontiers in Molecular Biosciences,
9,
2022
K. Kohoutova,
V. Docekal,
M. J. Ausserlechner,
N. Kaiser,
A. Tekel,
R. Mandal,
M. Horvath,
V. Obsilova
et al.
Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription
Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription
ACS Omega,
7(38),
2022
R. Mandal,
K. Kohoutova,
O. Petrvalska,
M. Horvath,
P. Srb,
V. Veverka,
V. Obsilova and
T. Obsil
FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA
FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA
Protein Science,
31(5),
2022
R. Joshi,
P. Pohl,
D. Strachotova,
P. Herman,
T. Obsil and
V. Obsilova
Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains
Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains
Biophysical Journal,
121(7),
2022
M. Horvath,
O. Petrvalska,
P. Herman,
V. Obsilova and
T. Obsil
14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites
14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites
Communications Biology,
4(986),
2021
V. Obsilova,
K. Honzejkova and
T. Obsil
Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions
Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions
International Journal of Molecular Sciences,
22(24),
2021
J. Hagenbuchner,
V. Obsilova,
T. Kaserer,
N. Kaiser,
B. Rass,
K. Psenakova,
V. Docekal,
M. Alblova
et al.
Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
eLife,
8,
e48876,
2020
D. L. Santo,
O. Petrvalska,
V. Obsilova,
C. Ottmann and
T. Obsil
Stabilization of Protein\textendashProtein Interactions between CaMKK2 and 14\textendash3\textendash3 by Fusicoccins
Stabilization of Protein\textendashProtein Interactions between CaMKK2 and 14\textendash3\textendash3 by Fusicoccins
ACS Chemical Biology,
15(11),
2020
V. Obsilova and
T. Obsil
The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases
The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases
International Journal of Molecular Sciences,
21(22),
2020
D. Kalabova,
F. Filandr,
M. Alblova,
O. Petrvalska,
M. Horvath,
P. Man,
T. Obsil and
V. Obsilova
14-3-3 protein binding blocks the dimerization interface of caspase-2
14-3-3 protein binding blocks the dimerization interface of caspase-2
The FEBS Journal,
287(16),
2020
A. Smidova,
K. Stankova,
O. Petrvalska,
J. Lazar,
H. Sychrova,
T. Obsil,
O. Zimmermannova and
V. Obsilova
The activity of Saccharomyces cerevisiae Na\mathplus, K\mathplus/H\mathplus antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481
The activity of Saccharomyces cerevisiae Na\mathplus, K\mathplus/H\mathplus antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
1866(12),
2019
K. Psenakova,
R. Hexnerova,
P. Srb,
V. Obsilova,
V. Veverka and
T. Obsil
The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress
The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress
The FEBS Journal,
287(8),
2019
K. Psenakova,
K. Kohoutova,
V. Obsilova,
M. J. Ausserlechner,
V. Veverka and
T. Obsil
Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics
Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics
Cells,
8(8),
966,
2019
M. Alblova,
A. Smidova,
D. Kalabova,
D. L. Santo,
T. Obsil and
V. Obsilova
Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein
Allosteric activation of yeast enzyme neutral trehalase by calcium and 14-3-3 protein
Physiol. Res.,
68(2),
147-160,
2019
A. Smidova,
M. Alblova,
D. Kalabova,
K. Psenakova,
M. Rosulek,
P. Herman,
T. Obsil and
V. Obsilova
14-3-3 protein masks the nuclear localization sequence of caspase-2
14-3-3 protein masks the nuclear localization sequence of caspase-2
The FEBS Journal,
285(22),
2018
S. Kylarova,
K. Psenakova,
P. Herman,
V. Obsilova and
T. Obsil
CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert
CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert
Biochimica et Biophysica Acta (BBA) - General Subjects,
1862(10),
2018
K. Psenakova,
O. Petrvalska,
S. Kylarova,
D. L. Santo,
D. Kalabova,
P. Herman,
V. Obsilova and
T. Obsil
14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)
14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2)
Biochimica et Biophysica Acta (BBA) - General Subjects,
1862(7),
2018
M. Alblova,
A. Smidova,
V. Docekal,
J. Vesely,
P. Herman,
V. Obsilova and
T. Obsil
Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1
Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1
Proceedings of the National Academy of Sciences,
114(46),
2017
M. Kacirova,
J. Novacek,
P. Man,
V. Obsilova and
T. Obsil
Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function
Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function
Biophysical Journal,
112(7),
2017
S. Kylarova,
D. Kosek,
O. Petrvalska,
K. Psenakova,
P. Man,
J. Vecer,
P. Herman,
V. Obsilova
et al.
Cysteine residues mediate high-affinity binding of thioredoxin to ASK1
Cysteine residues mediate high-affinity binding of thioredoxin to ASK1
The FEBS Journal,
283(20),
2016
O. Petrvalska,
D. Kosek,
Z. Kukacka,
Z. Tosner,
P. Man,
J. Vecer,
P. Herman,
V. Obsilova
et al.
Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)
Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)
Journal of Biological Chemistry,
291(39),
2016
M. Kacirova,
D. Kosek,
A. Kadek,
P. Man,
J. Vecer,
P. Herman,
V. Obsilova and
T. Obsil
Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein
Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein
Journal of Biological Chemistry,
290(26),
2015
D. Kosek,
S. Kylarova,
K. Psenakova,
L. Rezabkova,
P. Herman,
J. Vecer,
V. Obsilova and
T. Obsil
Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin
Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin
Journal of Biological Chemistry,
289(35),
2014
L. Rezabkova,
M. Kacirova,
M. Sulc,
P. Herman,
J. Vecer,
M. Stepanek,
V. Obsilova and
T. Obsil
Structural Modulation of Phosducin by Phosphorylation and 14-3-3 Protein Binding
Structural Modulation of Phosducin by Phosphorylation and 14-3-3 Protein Binding
Biophysical Journal,
103(9),
2012